Sexual desire can decrease over time as testosterone decreases, however there are other biologic and psychologic reasons for a man to lose his sexual desire. Biologic treatments include treating hypogonadism if that is the diagnosis. There are currently 2 medications FDA approved for premenopausal women that may be used for men: bremelanotide (Vyleesi) with is an injection used before sexual activity and flibanserin (Addyi) that is taken every night at bedtime.